Thermo Fisher Scientific IL-32 Recombinant Rabbit Monoclonal Antibody (403)

Applications

ELISA (ELISA)

• Tested Dilution: 1:1,000–1:10,000

Product Specifications

Additional Formats

• HRP
• Request custom conjugation

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• Better specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulations
• Broader immunoreactivity due to the larger rabbit immune repertoire

This antibody has specificity for Human IL32.

Target Information

Interleukin-32 (IL-32) was initially identified as a transcript (NK4) selectively expressed in lymphocytes and NK cells, with expression increased following activation by IL-2. It was later re-isolated from an IL-18-treated lung carcinoma cell line and renamed IL-32.

IL-32 is unique in that it does not share sequence homology with known cytokine families and is highly expressed in immune tissues, existing in at least four differentially spliced isoforms. Treatment of human monocytic and mouse macrophage cells with IL-32 induces proinflammatory cytokines such as TNF-α, IL-8, and MIP-2. It is also induced in human peripheral lymphocyte cells after mitogen stimulation and in epithelial cells by IFN-γ, suggesting a role in autoimmune and inflammatory diseases such as rheumatoid arthritis.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.