Thermo Fisher Scientific RFC1 Polyclonal Antibody

Thermo Fisher Scientific RFC1 Polyclonal Antibody

Applications

• Western Blot (WB): Tested Dilution 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Dog: 93% | Guinea Pig: 100% | Horse: 93% | Human: 100% | Mouse: 100% | Rabbit: 100% | Rat: 100%

Target Information

Replication factor C (RFC) is an essential DNA polymerase accessory protein required for numerous aspects of DNA metabolism, including DNA replication, DNA repair, and telomere metabolism. RFC is a heteropentameric complex that recognizes a primer on a template DNA, binds to a primer terminus, and loads proliferating cell nuclear antigen (PCNA) onto DNA at primer-template junctions in an ATP-dependent reaction.

All five RFC subunits share related sequences (RFC boxes) that include nucleotide-binding consensus sequences. Four of the five RFC genes (RFC1, RFC2, RFC3, and RFC4) have consensus ATP-binding motifs. The small RFC proteins (RFC2, RFC3, RFC4, and RFC5) interact with Rad24, whereas the RFC1 subunit does not. RFC2, the third-largest subunit of the RFC complex, exhibits ATP binding, making it important for both DNA replication and checkpoint function.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.