Thermo Fisher Scientific RIT1 Polyclonal Antibody
Rat RIT1 단백질을 인식하는 Rabbit Polyclonal 항체로 Western Blot에 최적화됨. N-말단 합성 펩타이드 면역원 사용. PBS 및 2% sucrose buffer에 보관되며 -20°C에서 안정적. Affinity chromatography로 정제되어 높은 특이성과 재현성을 제공.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1.0 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal region of rat RIT1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2689864 |
Product Specific Information
This target displays homology in the following species:
Cow: 79%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 79%; Zebrafish: 79%
Target Information
Rit and its neuron-specific homologue, Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated despite lacking a CAAX box or similar C-terminal lipidation motif. They display 64% amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100% conserved between murine and human proteins.
Although the effector domain sequences of Rit and Rin are similar to Ras, they interact with Ras-binding proteins such as RalGDS, Rlf, and AF-6, but not with Raf kinases, RIN1, or the p110 subunit of PI3 kinase. Therefore, Rit and Rin may play important roles in signaling pathways distinct from those controlled by Ras.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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