Thermo Fisher Scientific SEMA3F Polyclonal Antibody

Applications

• Western Blot (WB): 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 91%

Target Information

The semaphorins are a family of proteins involved in signaling. All members contain a secretion signal, a 500-amino acid sema domain, and 16 conserved cysteine residues (Kolodkin et al., 1993 [PubMed 8269517]).
Sequence comparisons have grouped the secreted semaphorins into three general classes, all containing an immunoglobulin domain.
The semaphorin III family, including human semaphorin III (SEMA3A; MIM 603961), chicken collapsin, and mouse semaphorins A, D, and E, possess a basic domain at the C terminus. Chicken collapsin contributes to axonal pathfinding during development by inhibiting growth cone extension (Luo et al., 1993 [PubMed 8402908]) through interaction with CRMP62 (Goshima et al., 1995 [PubMed 7637782]), a homolog of the UNC33 gene product (MIM 601168).
SEMA3F is a secreted member of the semaphorin III family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.