Thermo Fisher Scientific TPCN2 Polyclonal Antibody
TPCN2 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 다클론 항체로, Western blot 및 IHC(P)에서 검증됨. 인간 시료 반응성, 액상 형태, 0.5 mg/mL 농도. TBS 버퍼에 0.5% BSA 포함, -20°C 보관 권장.
- 카탈로그번호
- PA5142504
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3.75 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-EDELTERLSQHPH (aa 735–747) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933151 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:16,000.
Target Information
Tpcn2 is a nicotinic acid adenine dinucleotide phosphate (NAADP) receptor that may function as one of the major voltage-gated Ca(2+) channels (VDCC) across the lysosomal membrane.
It may also be involved in smooth muscle contraction. The Tpcn2 gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain.
The Tpcn2 protein localizes to lysosomal membranes and enables NAADP-induced calcium ion release from lysosome-related stores.
Tpcn2 is ubiquitously expressed, with elevated expression in liver and kidney.
Two common nonsynonymous SNPs in the Tpcn2 gene are strongly associated with blond versus brown hair pigmentation.
Diseases associated with TPCN2 include Deafness, Autosomal Recessive 63 and Deafness, Autosomal Recessive 7.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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