Thermo Fisher Scientific SKA3 Polyclonal Antibody
SKA3 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot 및 IHC(P)에서 검증됨. Human 시료 반응성, Goat 유래 IgG. 액상 형태로 0.5 mg/mL 농도, TBS 버퍼(0.5% BSA) 보존. 세포 분열 중 방추체 형성과 염색체 분리 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 3.75 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-PLSKTNSSSNDLE (aa 311–323) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933150 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
Target Information
Upon entry into mitosis, the cell’s microtubule (MT) network forms the mitotic spindle, allowing segregation of paired chromosomes. Proteinaceous structures on centromeric chromatin termed kinetochores (KT) are essential for proper attachment of chromosomes to spindle MTs.
A spindle and kinetochore complex composed of SKA1, SKA2, and SKA3 is required for stable KT-MT interactions and timely anaphase onset.
Depletion of SKA3 by siRNA delays anaphase transition, resulting in a prolonged metaphase-like state. These SKA3-depleted cells accumulate high levels of checkpoint protein Bub1 at kinetochores, suggesting that the SKA complex plays a key role in spindle checkpoint silencing and maintenance of chromosome cohesion during mitosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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