Thermo Fisher Scientific BCR-ABL Monoclonal Antibody (7C6)
BCR-ABL 단백질을 인식하는 Mouse monoclonal antibody (Clone 7C6). Western blot, IHC, ICC, IP 등 다양한 응용에 사용 가능. Human 및 Mouse 반응성. Protein A 정제, PBS/BSA buffer에 보관. CML 연구용으로 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| Immunoprecipitation (IP) | 5 µg |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7C6 |
| Immunogen | Bcr686 thyroglobulin conjugate corresponding to human BCR sequence 686–696 (SSINEEITPRRQS) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536861 |
Product Specific Information
Western blot analysis of MA1-153 detects ~130–160 kDa and a 210–250 kDa protein in K562 cells. In addition to BCR-ABL, BCR and ABL are also expressed in these cells, and full-length BCR is also detected by the antibody. Under non-reducing conditions, enhanced detection of BCR-ABL is observed.
Target Information
A reciprocal translocation between chromosomes 22 and 9 produces the BCR-ABL fusion oncoprotein, which is found in patients with chronic myelogenous leukemia (CML). The p210 form is the most common variant. The fusion leads to constitutive tyrosine kinase activation, driving oncogenic transformation of myeloid cells. Inhibition of BCR-ABL activity by the ABL-kinase inhibitor STI-571 (imatinib, Gleevec) represents a landmark in targeted cancer therapy. Mutations such as T351I have been associated with resistance, prompting further drug development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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