Thermo Fisher Scientific Dicer Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–10 µg/mg lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

Dicer is a double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. It cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of 21–23 nucleotides with a 3′ overhang of two nucleotides, producing short interfering RNAs (siRNA) and mature microRNAs.
SiRNAs and miRNAs guide the RNA-induced silencing complex (RISC) to complementary RNAs for degradation or translational repression.
RNA interference (RNAi) mediated by siRNAs regulates the elimination of transcripts from mobile and repetitive DNA elements and the degradation of exogenous viral RNA. The miRNA pathway specifically regulates expression of target genes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.