Thermo Fisher Scientific Crystallin Alpha B Monoclonal Antibody (CRYAB/4665)
인간 CRYAB 단백질을 인식하는 Mouse 모노클로날 항체로, IHC 및 Peptide Array 등 다양한 응용에 적합. 단백질 A/G로 정제된 액상 형태이며, PBS(pH 7.4) 버퍼에 보존제 없이 제공. -20°C에서 보관하며 연구용으로만 사용 가능.
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- 1410MSM15P1ABX
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Thermo Fisher Scientific Crystallin Alpha B Monoclonal Antibody (CRYAB/4665)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CRYAB/4665 |
| Immunogen | Recombinant human full-length CRYAB protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index.
The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma. Alpha-crystallin is the largest and composed of two primary gene products—alpha-A and alpha-B.
Alpha-crystallin comprises about 40% of total lens protein composition and functions as a chaperone, preventing aggregate formation that may lead to cataracts.
Phosphorylated states of alpha-crystallin may occur in response to cellular stress and play roles in structural control and protein maintenance.
Alpha-B crystallin has been linked to Alexander’s disease, where it accumulates in brain cells of affected individuals.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: 1410-MSM15-P1ABX_CRYAB_P02511-1_House_mouse_PDP.jpeg)
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