Thermo Fisher Scientific Crystallin Alpha B Monoclonal Antibody (CRYAB/7917)
Human CRYAB 단백질을 인식하는 마우스 단클론 항체로, IHC(P) 및 IHC(PFA) 실험에 적합합니다. 단백질 A/G로 정제된 액상 형태이며, 4°C에서 보관합니다. 렌즈 단백질 연구 및 알파 크리스탈린 관련 질병 연구에 활용 가능합니다.
- 카탈로그번호
- 1410-MSM17-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Crystallin Alpha B Monoclonal Antibody (CRYAB/7917)
Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CRYAB/7917 |
| Immunogen | Recombinant human full-length CRYAB protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Lens proteins consist almost entirely of crystallins (about 95%). Crystallins are also found in vertebrate skeletal muscle tissue. In the lens, their structural function is to assist in maintaining the proper refractive index. The mammalian lens contains three major classes of crystallins: alpha, beta, and gamma.
Alpha-crystallin is the largest and composed of two primary gene products—alpha-A and alpha-B. Alpha-B crystallin functions as a molecular chaperone, preventing aggregate formation that may lead to cataract development. Phosphorylated states of alpha-crystallin respond to cellular stress and may play a structural control role in protein maintenance.
Alpha-B crystallin has been linked to Alexander’s disease, where it accumulates in brain cells of affected individuals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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