Thermo Fisher Scientific CD366 (TIM3) Monoclonal Antibody (F38-2E2), PE-eFluor 610, eBioscience
인간 CD366(TIM3)을 인식하는 F38-2E2 단클론 항체로, PE-eFluor 610 형광체가 결합된 제품입니다. Flow Cytometry용으로 최적화되어 있으며, 488–561 nm 레이저로 여기되어 607 nm에서 방출합니다. 면역조절 및 자가면역 연구에 적합합니다.
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Thermo Fisher Scientific CD366 (TIM3) Monoclonal Antibody (F38-2E2), PE-eFluor 610
Applications
- Western Blot (WB): Not tested
- Flow Cytometry (Flow): 5 µL (0.25 µg)/test
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), PE-eFluor™ 610 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | F38-2E2 |
| Conjugate | PE-eFluor™ 610 |
| Excitation / Emission Max | 565 / 606 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2802391 |
Available Formats
- Alexa Fluor 532
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Brilliant UV 805
- Brilliant Violet 605, 650, 786
- FITC
- Functional Grade
- PE, PE-Cyanine5, PE-Cyanine5.5, PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436, 600, 645, 702, 780
- Request custom conjugation
Product Specific Information
This F38-2E2 monoclonal antibody reacts with human CD366 (TIM3, HAVCR2). CD366 is a cell surface receptor expressed on activated CD4+ T cell subsets (Th1, Th17, Treg), CD8+ T cells, monocytes, dendritic cells, and mast cells. Galectin-9 is its known ligand, and CD366 plays a role in negative regulation of CD4+ T cells, tolerance, autoimmune disease, and HIV infection.
- Applications Reported: Flow cytometric analysis
- Applications Tested: Pre-diluted and tested by flow cytometry on human peripheral blood cells
- Recommended: 5 µL (0.25 µg)/test (100 µL final volume)
- Cell number: 10⁵–10⁸ cells/test (empirical)
Fluorochrome Characteristics:
- Excitation: 488–561 nm
- Emission: 607 nm
- Recommended filter: 610/20 band pass (PE-Texas Red equivalent)
- Light sensitivity: Protect from light (photo-induced oxidation)
- Fixation: Samples can be stored in IC Fixation Buffer (Product #00-8222-49) or 1-step Fix/Lyse Solution (Product #00-5333-57) up to 3 days at 4°C in dark.
Target Information
TIM3 (HAVCR2) is a 281 amino acid, type-1 Th1-specific cell surface glycoprotein expressed on terminally differentiated CD4+Th1 and CD8+Tc1 cells. It contains:
- IgV-like domain
- Mucin-like extracellular domain
- Tyrosine phosphorylation motif in cytoplasmic region
TIM3 is involved in macrophage activation, autoimmune disease induction, and immune tolerance regulation. It is linked to experimental autoimmune encephalomyelitis (EAE) and Th1-mediated immune responses.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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