Thermo Fisher Scientific MSC Polyclonal Antibody
Rabbit polyclonal antibody targeting human MSC protein. Suitable for IHC(P) applications with high purity (>95%) and antigen affinity purification. Reacts with human, mouse, and rat. Provided as liquid form, unconjugated, for research use only.
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Applications
- Immunohistochemistry (Paraffin) [IHC (P)]
Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 141–190 of Human MSC |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2718944 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum using an epitope-specific immunogen. The purity is >95% as determined by SDS-PAGE.
Target Information
MyoD-E or musculin-E heterodimers bind strongly to consensus E box motifs, which are key elements in promoter regions of many muscle-specific terminal differentiation genes.
MyoD complexes induce transcriptional activation, whereas musculin complexes bind adjacent to MyoD DNA-binding regions to repress MyoD activity, leading to delayed expression of muscle-specific genes.
Musculin is highly expressed in undifferentiated and proliferating myoblasts in culture, and its expression is downregulated during myogenesis and at the onset of terminal differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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