Thermo Fisher Scientific MRPL28 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:3,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human, Mouse, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human MRPL28(Accession Q13084), corresponding to amino acid residues L146-I196. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:MRPL28,uniProtId:Q13084-1,ncbiNodeId:9606,antigenRange:146-196,antigenLength:256,antigenImageFileName:PA5-103523_MRPL28_Q13084-1_Rabbit.svg,antigenImageFileNamePDP:PA5-103523_MRPL28_Q13084-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2852859

Product Specific Information

Antibody detects endogenous levels of total MRPL28.

Target Information

MRP-L28 (39S ribosomal protein L28, melanoma-associated antigen recognized by T lymphocytes) is a mitochondrial protein that belongs to the ribosomal protein L28P family. MRP-L28 potentially represents an important therapeutic reagent for HLA-A24 (A24) patients as this antigen is recognized by tumor-infiltrating lymphocyte (TIL) 1290, which targets the A24 serotype. HLAA24 (A24) is an HLA-A serotype that identifies the more common HLA-A24 gene products. A24 is a split antigen that is also recognized by the A9 broad antigen type and the similar A23 types. A24 is common in Austronesia and has one of the highest A allele frequencies for a number of peoples, including Papua New Guineans, indigeonous Taiwanese (eastern tribals), Yupik and Greenland Eskimos. MRP-L28 is found in a variety of normal tissues including spleen, testis, thymus, liver, kidney, brain, adrenal, lung and retinal tissue.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.