Thermo Fisher Scientific CHCHD6 Polyclonal Antibody
CHCHD6 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(Paraffin)에서 사용 가능. Human 및 Rat 시료에 반응하며, Affinity chromatography로 정제됨. PBS/glycerol buffer에 보관하며 -20°C에서 안정적. 연구용으로만 사용.
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- PA5100091
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CHCHD6 (Accession Q9BRQ6), corresponding to amino acid residues K165–V215 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2815621 |
Product Specific Information
Antibody detects endogenous levels of total CHCHD6.
Target Information
CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and is found in a complex with mitochondrial proteins such as mitofilin, SAM50, metaxins 1 and 2, and CHCHD3.
Knockdown of CHCHD6 causes defects in mitochondrial cristae morphology, reduced cell growth, ATP production, and oxygen consumption.
CHCHD6 reduction also decreases mitofilin levels, and vice versa, indicating coordinated regulation.
Furthermore, CHCHD6 knockdown in human cancer cells increases sensitivity to genotoxic anticancer drugs, suggesting CHCHD6 as a potential therapeutic anti-tumor target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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