Thermo Fisher Scientific BID Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.5–5 µg/mL

Product Specifications

Product Specific Information

PA1-26485 detects Bid from mouse samples.

Target Information

BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. It is a member of the BCL-2 family of cell death regulators and mediates mitochondrial damage induced by caspase-8 (CASP8). CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria, triggering cytochrome c release. BID usually exists in an inactive form in the cytosol and becomes cleaved and activated by caspase 8 in response to TNF alpha or Fas ligand. The cleaved C-terminal fragment (p15) translocates to mitochondria, inducing apoptosis. BID serves as a direct molecular link between caspase 8 activation and mitochondrial death machinery.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: PA1-26485_BID_P70444-1_Rabbit.svg, PA1-26485_BID_P70444-1_Rabbit_PDP.jpeg)