Thermo Fisher Scientific GAS2L1 Polyclonal Antibody
GAS2L1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot과 IHC(Paraffin)에서 검증됨. 인간, 마우스, 랫트 반응성. Affinity chromatography로 정제되었으며, PBS/glycerol buffer에 보관. 세포 골격 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human GAS2L1 (Accession Q99501), corresponding to amino acid residues C624–R674 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851988 |
Product Specific Information
Antibody detects endogenous levels of total GAS2L1.
Target Information
The Gas2 protein is thought to play a role in apoptosis by acting as a cell death substrate for caspases. Gas2, a component of the microfilament system, is cleaved by caspase-3 or caspase-7 at Asparagine 278 during apoptosis. The cleaved form of Gas2 induces rearrangement of the actin cytoskeleton and causes morphological changes in affected cells.
Gas2 is a cytoskeleton and peripheral membrane protein that co-localizes with actin fibers at the cell border and along stress fibers in growth-arrested fibroblasts. It is mainly membrane-associated, but when hyperphosphorylated, it accumulates at membrane ruffles, indicating its involvement in that process.
Gar22 (Gas2-related protein on chromosome 22), also known as growth arrest-specific protein 2-like 1 (Gas2-like1), belongs to the Gas2 family and contains one calponin-homology (CH) domain. It is thought to participate in cross-linking microtubules and microfilaments.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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