Thermo Fisher Scientific GAS2L1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Antibody detects endogenous levels of total GAS2L1.

Target Information

The Gas2 protein is thought to play a role in apoptosis by acting as a cell death substrate for caspases. Gas2, a component of the microfilament system, is cleaved by caspase-3 or caspase-7 at Asparagine 278 during apoptosis. The cleaved form of Gas2 induces rearrangement of the actin cytoskeleton and causes morphological changes in affected cells.

Gas2 is a cytoskeleton and peripheral membrane protein that co-localizes with actin fibers at the cell border and along stress fibers in growth-arrested fibroblasts. It is mainly membrane-associated, but when hyperphosphorylated, it accumulates at membrane ruffles, indicating its involvement in that process.

Gar22 (Gas2-related protein on chromosome 22), also known as growth arrest-specific protein 2-like 1 (Gas2-like1), belongs to the Gas2 family and contains one calponin-homology (CH) domain. It is thought to participate in cross-linking microtubules and microfilaments.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.