Thermo Fisher Scientific EAAT4 Polyclonal Antibody
EAAT4 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, 마우스 및 랫트 시료에 반응합니다. WB 및 IHC 분석에 적합하며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of mouse EAAT4. The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.28 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2902042 |
Product Specific Information
- Centrifuge briefly prior to opening.
Target Information
Slc1a6 encodes a protein that functions as a glutamate transporter, also known as excitatory amino acid transporter (EAAT). These are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1), widely distributed throughout the brain.
There are five EAAT subtypes, each with specific distribution. EAAT4 mediates uptake of L-glutamate, L-aspartate, and D-aspartate, functioning as a symporter transporting one amino acid molecule together with two or three Na⁺ ions and one proton, counter-transporting one K⁺ ion.
It also mediates Cl⁻ flux to prevent charge accumulation. EAAT4 plays a redundant role in rapid removal of released glutamate from the synaptic cleft, essential for terminating postsynaptic glutamate action.
Diseases associated with SLC1A6 include Dicarboxylic Aminoaciduria.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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