Thermo Fisher Scientific EAAT4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1,000

Product Specifications

Product Specific Information

• Centrifuge briefly prior to opening.

Target Information

Slc1a6 encodes a protein that functions as a glutamate transporter, also known as excitatory amino acid transporter (EAAT). These are sodium- and potassium-dependent members of the solute carrier family 6 (SLC1), widely distributed throughout the brain.
There are five EAAT subtypes, each with specific distribution. EAAT4 mediates uptake of L-glutamate, L-aspartate, and D-aspartate, functioning as a symporter transporting one amino acid molecule together with two or three Na⁺ ions and one proton, counter-transporting one K⁺ ion.
It also mediates Cl⁻ flux to prevent charge accumulation. EAAT4 plays a redundant role in rapid removal of released glutamate from the synaptic cleft, essential for terminating postsynaptic glutamate action.
Diseases associated with SLC1A6 include Dicarboxylic Aminoaciduria.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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