Thermo Fisher Scientific TNF alpha Monoclonal Antibody (MAb11), Alexa Fluor 660, eBioscience
인간 TNF alpha를 인식하는 중화성 단클론 항체로, Alexa Fluor 660 형광 표지. Flow cytometry용으로 최적화되어 있으며, 세포 내 염색에 사용 가능. 4°C 보관, 동결 금지. 연구용으로만 사용.
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Thermo Fisher Scientific TNF alpha Monoclonal Antibody (MAb11), Alexa Fluor 660, eBioscience
Applications
- Flow Cytometry (Intracellular staining)
Tested Dilution: 5 µL (0.125 µg)/test
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Alexa Fluor™ 660, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | MAb11 |
| Conjugate | Alexa Fluor™ 660 |
| Excitation / Emission Max | 663 / 691 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2896305 |
Available Formats
- Unconjugated
- Alexa Fluor 488
- Alexa Fluor 700
- APC
- Biotin
- Brilliant UV 661
- Brilliant UV 737
- Brilliant Violet 421
- Brilliant Violet 650
- eFluor 450
- FITC
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-Cyanine5.5
- Request custom conjugation
Product Specific Information
The MAb11 antibody reacts with human tumor necrosis factor-alpha (TNF alpha), a 17 kDa cytokine produced by monocytes, macrophages, neutrophils, NK cells, and CD4+ T cells. TNF alpha exhibits cytolytic activity against various tumor cells and plays an important role in immune regulation. It exists as soluble dimers and trimers or as a 26 kDa membrane-bound form.
MAb11 is a neutralizing antibody suitable for intracellular staining followed by flow cytometric analysis. Tested using the Intracellular Fixation & Permeabilization Buffer Set (Product #88-8824-00) at 5 µL (0.125 µg) per test. A test is defined as staining a sample in 100 µL final volume (typically 10^5–10^8 cells/test).
Alexa Fluor 660 emits at 690 nm and is ideal for spectral cytometry multiplexing with APC, Alexa Fluor 647, and Alexa Fluor 700.
Excitation: 662 nm Emission: 690 nm Laser: Red Laser.
Target Information
TNF alpha is a multifunctional proinflammatory cytokine belonging to the TNF superfamily. Secreted mainly by macrophages, it binds to receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR.
It regulates immune responses, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha forms multimers (dimers, trimers, pentamers) and shows a single 17 kDa band under non-reducing SDS-PAGE.
Mouse knockout studies suggest a neuroprotective role. TNF alpha induces tumor necrosis and participates in immune responses against bacterial, viral, parasitic, and fungal infections. It acts synergistically with interferon-gamma in cytotoxicity and is implicated in autoimmune diseases, insulin resistance, and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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