Thermo Fisher Scientific Phospho-B-Myb (Ser577, Ser581) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

Nucleocytoplasmic transport, a signal- and energy-dependent process, occurs through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the importin alpha/beta heterodimer, also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm, and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP-binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein, while importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential for translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.