Thermo Fisher Scientific MAPK15 Polyclonal Antibody
MAPK15 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human, Mouse, Rat에 반응합니다. Western blot, ELISA, Immunoprecipitation에 적합하며, 합성 펩타이드(aa 500-544)를 면역원으로 사용했습니다. 연구용으로 세포 성장 및 신호전달 연구에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 500–544 of human MAPK15 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The ERKs are a subfamily of MAPKs involved in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase regulated by serum and c-Src non-receptor tyrosine kinase. ERK8 down-regulates glucocorticoid receptor transactivation through Hic-5 and can negatively regulate transcriptional co-activation of androgen receptor and GRα by Hic-5 in a kinase-independent manner, suggesting a broader role in nuclear receptor regulation. Erk8 also acts as a novel effector of RET/PTC3, contributing to RET biological functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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