Thermo Fisher Scientific MAPK15 Polyclonal Antibody, Biotin
MAPK15 단백질을 인식하는 Biotin-conjugated rabbit polyclonal antibody로, WB, ELISA, IP에 사용 가능. Human, Mouse, Rat 반응성. Affinity chromatography로 정제되었으며, 안정한 보관을 위한 glycerol 및 BSA 함유. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 500–544 of human Mitogen-activated protein kinase 15 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ERKs are a subfamily of MAPKs involved in cell growth and differentiation. Extracellular signal-regulated kinase 8 (Erk8) is a large MAP kinase regulated by serum and the c-Src tyrosine kinase. ERK8 down-regulates glucocorticoid receptor transactivation via Hic-5 and can negatively regulate androgen receptor and GRα co-activation in a kinase-independent manner. This suggests a broader role for ERK8 in regulating nuclear receptors beyond estrogen receptor α. Erk8 also acts as a novel effector of RET/PTC3, implicating it in RET biological functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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