Thermo Fisher Scientific NMDAR2B Polyclonal Antibody
다종(인간, 마우스, 랫트)에 반응하는 NMDAR2B 폴리클로날 항체. Western blot, IHC, ICC 등 다양한 응용 가능. 뇌 신경 발달 및 기억 관련 연구에 적합. 동결 건조 형태로 -20°C에서 장기 보관 가능.
- 카탈로그번호
- A6474
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific NMDAR2B Polyclonal Antibody
Thermo Fisher Scientific NMDAR2B Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100–1:2,000 | View 8 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:500–1:5,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | – | View 2 publications |
| ELISA | Assay-dependent | – |
| Immunoprecipitation (IP) | 3 µL | – |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein containing amino acid residues 984–1104 of the C-terminal region of rat brain subunit 2B |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | IgG fraction |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536210 |
Product Specific Information
This antibody is specific for the ~180 kDa 2B subunit from rat, mouse, and human.
Storage and Reconstitution:
- Store lyophilized antibody at –20°C or below for over one year of full activity.
- Reconstitute using 50 µL PBS (pH 7.4) to yield a 0.2 mg/mL solution.
- For storage at 0–4°C, add sodium azide to a final concentration of 2 mM.
- For long-term storage, aliquot and freeze at –20°C, avoiding freeze/thaw cycles.
Target Information
NMDAR2B is a member of the N-methyl-D-aspartate (NMDA) class of ionotropic glutamate receptors. These receptors are involved in long-term potentiation, which enhances synaptic transmission efficiency and contributes to memory and learning.
NMDAR plays roles in neuronal development and has been implicated in central nervous system disorders such as Alzheimer’s disease, epilepsy, and ischemic neuronal cell death.
Overexpression of the NR2B subunit correlates with improved learning and memory, while aged, memory-impaired animals show NR2B deficiencies.
Phosphorylation at Tyr1472 may increase NMDAR expression at synapses, contributing to synaptic plasticity.
NMDAR2B forms a heterotrimer composed of NR1, NR2, and NR3 subunits.
Diseases associated with NMDAR2B dysfunction include epileptic encephalopathy and autosomal dominant 6-related mental retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.