Thermo Fisher Scientific FBXW8 Polyclonal Antibody
FBXW8 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, ICC/IF, ELISA에 적합하며 인간, 마우스, 랫트 반응성. 고순도 친화 크로마토그래피 정제, 액상 형태로 -20°C 보관.
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- PA5116803
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Thermo Fisher Scientific FBXW8 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 500–598 of human FBXW8 (NP_699179.2) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.46 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901434 |
Product Specific Information
- Positive Samples: U-87MG, A-549, A-431, Rat lung, Rat heart
- Immunogen Sequence:
WDYRMNQKLW EVYSGHPVQH ISFSSHSLIT ANVPYQTVMR NADLDSFTTH RRHRGLIRAY EFAVDQLAFQ SPLPVCRSSC DAMATHYYDL ALAFPYNHV
Target Information
FBXW8 encodes a member of the F-box protein family, characterized by an approximately 40 amino acid F-box motif. These proteins form part of the ubiquitin ligase complex SCF (SKP1–Cullin–F-box), which mediates phosphorylation-dependent ubiquitination.
F-box proteins are categorized into:
- Fbws: Containing WD-40 domains
- Fbls: Containing leucine-rich repeats
- Fbxs: Containing other interaction modules or no recognizable motifs
FBXW8 contains both an F-box motif and a WD-40 domain, classifying it as an Fbw protein.
Alternatively spliced transcript variants encoding distinct isoforms have been identified.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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