Thermo Fisher Scientific SOX1 Recombinant Rabbit Monoclonal Antibody (JJ20-40)
SOX1 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot, IHC, ICC 등 다양한 응용에 적합합니다. 높은 특이성과 재현성을 제공하며, HEK293 세포에서 발현된 IgG 형식의 항체입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:50–1:100 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JJ20-40 |
| Immunogen | Synthetic peptide within Human SOX1 (aa 1–50) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809724 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages include:
- Improved specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to the rabbit immune repertoire
Target Information
SOX1 (SRY-box 1) is a transcription factor belonging to the SRY-related HMG box family with a DNA-binding HMG domain.
It promotes neuronal cell fate determination and differentiation, modulates LINE retroposon promoter activity, and is involved in central nervous system and lens development.
SOX1 binds to the HES1 promoter to suppress transcription (attenuating Notch signaling) and also interacts with β-catenin to inhibit TCF/LEF-mediated transcription (affecting WNT signaling).
Expression is primarily observed in embryonic tissues and moderately in the brain.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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