Thermo Fisher Scientific JNK3 Polyclonal Antibody
JNK3 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, IP 등 다양한 응용에 적합합니다. Human 및 Mouse 시료에 반응하며, 고순도의 액상 형태로 제공됩니다. 신경세포 아포토시스 연구 및 MAPK 신호전달 경로 분석에 유용합니다.
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- PA514421
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- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Immunoprecipitation (IP) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 1–30 of the N-terminal region of human MAPK10 (JNK3) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion chromatography, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2141451 |
Target Information
MAPK10 (JNK3) is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). It is involved in neuronal apoptosis and phosphorylates MAP2K4. MAP kinases act as integration points for multiple biochemical signals and are involved in cellular processes such as proliferation, differentiation, transcription regulation, and development.
This kinase plays regulatory roles in neuronal apoptosis through phosphorylation and nuclear localization. Beta-arrestin 2 interacts with and stimulates its phosphorylation by MAP kinase kinase 4 (NhpK4). Cyclin-dependent kinase 5 can phosphorylate and inhibit JNK3 activity, potentially preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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