Thermo Fisher Scientific MA2 Polyclonal Antibody
Rabbit polyclonal antibody recognizing human MA2 protein. Validated for Western blot (1:500–1:1,000). Suitable for research on paraneoplastic neurological syndromes. Supplied as liquid at 0.5 mg/mL, store at 4°C short term or -20°C long term.
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Applications and Tested Dilution
- Western Blot (WB): 1:500–1:1,000
- Suggested positive control: SK-N-SH cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues 143–158 of human MA2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2167635 |
Target Information
In patients with cancer, symptoms of limbic and brain-stem dysfunction may result from a paraneoplastic disorder. Two proteins, Ma1 and Ma2, were discovered by the presence of autoantibodies against them. Antibodies to Ma1 and Ma2 proteins identify a paraneoplastic disorder that affects the limbic system, brain stem, and cerebellum. These autoantibodies were used to clone Ma2, which codes for a protein recognized by serum from patients but not by serum from control subjects. Ma2 is selectively expressed by normal brain tissue and by testicular tumors. Ma2 shares homology with Ma1, a “brain-testis-cancer” gene related to other paraneoplastic syndromes and tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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