Thermo Fisher Scientific KLHL1 Polyclonal Antibody
KLHL1 단백질을 인식하는 Rabbit Polyclonal 항체로, WB와 IHC에 사용 가능. 인간 및 랫트 시료에 반응하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태로 제공되며 1 mg/mL 농도. 연구용으로만 사용.
- 카탈로그번호
- PA519998
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–4 µg/mL |
| Immunohistochemistry (IHC) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide from near the amino-terminus of human KLHL1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152847 |
Product Specific Information
- Suggested positive control: human brain tissue lysate
- PA5-19998 can be used with blocking peptide PEP-0120
Target Information
The mammalian Kelch-like 1 (KLHL1) was initially discovered as a homolog to the Drosophila Kelch gene that is highly expressed in several brain tissues.
The predicted protein domain structure of KLHL1 is characteristic of a number of proteins that bind actin, form dimers, and often act as actin-organizing proteins.
Based on the presence of anti-sense RNA that spans the transcription and translation start sites as well as the first splice site of KLHL1 in brain tissue of individuals suffering from the neurodegenerative disorder spinocerebellar ataxia type 8 (SCA8), it has been suggested that KLHL1 is involved in this disease and that regulation of KLHL1 protein may be affected by antisense RNA expression.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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