Thermo Fisher Scientific KLHL1 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

• Suggested positive control: human brain tissue lysate
• PA5-19998 can be used with blocking peptide PEP-0120

Target Information

The mammalian Kelch-like 1 (KLHL1) was initially discovered as a homolog to the Drosophila Kelch gene that is highly expressed in several brain tissues.
The predicted protein domain structure of KLHL1 is characteristic of a number of proteins that bind actin, form dimers, and often act as actin-organizing proteins.
Based on the presence of anti-sense RNA that spans the transcription and translation start sites as well as the first splice site of KLHL1 in brain tissue of individuals suffering from the neurodegenerative disorder spinocerebellar ataxia type 8 (SCA8), it has been suggested that KLHL1 is involved in this disease and that regulation of KLHL1 protein may be affected by antisense RNA expression.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.