Thermo Fisher Scientific Human SRPK2, GST Tag Recombinant Protein
인간 SRPK2 단백질을 GST 태그로 발현한 재조합 단백질로, HBV 감염 연구 및 키나아제 활성 분석에 적합합니다. 곤충 세포에서 발현되었으며 고순도 정제 상태로 제공됩니다. -80°C 보관 시 안정성이 유지됩니다.
- 카테고리
- Protein
- 판매단위
- pk
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Thermo Fisher Scientific Human SRPK2, GST Tag Recombinant Protein
Applications
- Kinase Assay (KA)
Tested Dilution: Assay-dependent
Publications: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | Insect cells |
| Amino Acid Sequence | Full length |
| Tag | GST-tag |
| Molecular Weight | 105 kDa |
| Class | Recombinant |
| Type | Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Purified |
| Storage Buffer | 50 mM Tris, pH 7.5, with 2 mM DTT, 50% glycerol, 0.5 mM EDTA, 150 mM NaCl, 0.02% Triton X-100 |
| Contains | No preservative |
| Storage Conditions | -80°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Dry ice |
Product Specific Information
- For maximum recovery, please spin prior to use.
- Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use material directly from original packaging.
- For larger sizes, aliquoting can reduce freeze/thaw cycles; aliquots below 20 µL are not recommended.
- Do not store kinase in diluted form.
- Properly stored at -80°C, product is guaranteed for 6 months from date of purchase.
Protein Form: Full Length
Target Information
SRPK2, along with SRPK1, is likely the cellular protein kinase mediating HBV core protein phosphorylation during viral infection, representing an important host cell target for therapeutic intervention.
It promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression through phosphorylation of SRSF2, suppressing p53/TP53 phosphorylation and relieving repression on cyclin-D1 expression.
Phosphorylates ACIN1, redistributing it from nuclear speckles to nucleoplasm, leading to cyclin A1 up-regulation.
Plays a key role in spliceosomal B complex formation via phosphorylation of DDX23/PRP28.
Negatively regulates HBV replication by reducing packaging efficiency of pregenomic RNA (pgRNA) without affecting viral core particle formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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