Thermo Fisher Scientific Human IKBKB (IKK Beta), GST Tag Recombinant Protein
Human IKBKB (IKK Beta) GST-tagged recombinant protein for kinase assays and NF-κB pathway studies. Expressed in insect cells, purified liquid form. Stable at -80°C, designed for research use only.
- 카탈로그번호
- PR7489x (2개 옵션)
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human IKBKB (IKK Beta), GST Tag Recombinant Protein
Applications
- Kinase Assay (KA)
Tested Dilution
- Assay-dependent
Publications
- [References not provided]
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | Insect cells |
| Amino Acid Sequence | Full length |
| Tag | GST-tag |
| Molecular Weight | 114 kDa |
| Class | Recombinant |
| Type | Protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Purified |
| Storage Buffer | 50 mM Tris, pH 7.5, with 0.5 mM EDTA, 50% glycerol, 150 mM NaCl, 2 mM DTT, 0.02% Triton X-100 |
| Contains | No preservative |
| Storage Conditions | -80°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Dry ice |
Product Specific Information
For maximum recovery, please spin prior to use.
Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use material in original packaging until exhausted.
For larger sizes, reduce freeze/thaw cycles by preparing aliquots (do not prepare aliquots below 20 µL).
Never store kinase diluted.
If properly stored at -80°C, product stability is guaranteed for 6 months from purchase date.
Protein Form: Recombinant, Full Length
Target Information
IKBKB (IKK beta) phosphorylates serine residues on I-kappa-B proteins, marking them for degradation via ubiquitination and enabling NF-kappa-B activation.
This serine kinase is essential in the NF-kappa-B signaling pathway, activated by inflammatory cytokines, bacterial or viral products, DNA damage, and other stresses.
IKK beta functions within the canonical IKK complex, phosphorylating NF-kappa-B inhibitors on critical serine residues, leading to their polyubiquitination and proteasomal degradation.
Free NF-kappa-B then translocates to the nucleus to activate transcription of genes involved in immune response, growth control, and apoptosis protection.
Mutations in the IKK beta gene can cause Immunodeficiency 15 (IMD15).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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