Thermo Fisher Scientific SPHK1 Polyclonal Antibody
SPHK1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot과 Immunocytochemistry에 적합하며, 고순도 항원 친화 크로마토그래피로 정제됨. 세포 신호전달 연구 및 암 관련 기전 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human SPHK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792385 |
Product Specific Information
- Keep as concentrated solution.
- Positive Control: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
SPHK1, along with SPHK2, catalyzes the phosphorylation of sphingosine producing sphingosine-1-phosphate (S1P), a key signaling molecule.
S1P acts through G-protein coupled receptors to regulate cell differentiation, calcium mobilization, and apoptosis.
SPHK inhibitors are potential therapeutics for cancer treatment.
S1P interacts with EDG family G protein-coupled receptors (S1P Receptors) to mediate diverse cellular processes.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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