Thermo Fisher Scientific IKK beta Polyclonal Antibody
IKK beta 단백질을 표적하는 Rabbit Polyclonal 항체로, 인간, 마우스, 랫트에 반응합니다. IHC(P)에서 1:50–1:200 희석으로 사용 가능하며, NF-κB 신호전달 연구에 유용합니다. 항원 친화 크로마토그래피로 정제된 고순도 항체입니다.
- 판매단위
- pk
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 171–220 of Human IKKβ |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2803069 |
Product Specific Information
- Purity > 95% by SDS-PAGE.
Target Information
IKK beta (Inhibitor of nuclear factor kappa-B kinase subunit beta) is a serine kinase essential to the NF-κB signaling pathway. Phosphorylation of IκB proteins by IKK kinases, including IKBKB, leads to their ubiquitination and degradation, allowing NF-κB activation. This pathway is triggered by inflammatory cytokines, bacterial or viral products, DNA damage, and other cellular stresses. IKK beta functions as part of the canonical IKK complex, phosphorylating inhibitors of NF-κB on key serine residues, enabling NF-κB translocation to the nucleus and activation of genes involved in immune response, cell growth, and anti-apoptotic processes. Mutations in the IKK beta gene can lead to Immunodeficiency 15 (IMD15).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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