Thermo Fisher Scientific alpha 1A-Adrenergic Receptor (extracellular) Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Reconstitution: Add 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week; for longer periods, aliquot and store at -20°C.
Avoid multiple freeze-thaw cycles. Centrifuge all antibody preparations before use (10,000 × g for 5 min).

Target Information

Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind endogenous catecholamines epinephrine and norepinephrine.
Nine receptor subtypes have been identified: three alpha-1 (1A/D, 1B, 1C), three alpha-2 (2A, 2B, 2C), and three beta (1, 2, 3).
ARs are involved in disease states such as hypertension, cardiac dysfunction, diabetes, glaucoma, depression, and impotence.
A1AR subtypes regulate blood pressure via vascular tone and cardiac output, and are linked to uterine contraction, hepatic glucose metabolism, HSP70 expression, proto-oncogene activation, and mitogenesis.
Norepinephrine can increase nitric oxide synthase (NOS) levels in the hypothalamus via alpha-1 AR activation, potentially suppressing luteinizing hormone (LH) and steroid hormone release.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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