Thermo Fisher Scientific CHRM2 Polyclonal Antibody
CHRM2 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, 인간 시료에 반응합니다. Western blot과 ELISA에 적합하며, 고순도 Affinity Chromatography로 정제되어 있습니다. 액상 형태로 제공되며, 안정적인 PBS/glycerol buffer에 보존됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 208–388 of human Muscarinic AChR M2 (ACM2) (NP_0010066291) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.99 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2806142 |
Product Specific Information
Immunogen sequence:
HISRASKSRI KKDKKEPVAN QDPVSPSLVQ GRIVKPNNNN MPSSDDGLEH NKIQNGKAPR DPVTENCVQG EEKESSNDST SVSAVASNMR DDEITQDENT VSTSLGHSKD ENSKQTCIRI GTKTPKSDSC TPTNTTVEVV GSSGQNGDEK QNIVARKIVK MTKQPAKKKP PPSREKKVTR T
Positive Samples: SH-SY5Y, HepG2
Cellular Location: Cell junction, cell membrane, multi-pass membrane protein, postsynaptic cell membrane, synapse
Target Information
Muscarinic cholinergic receptor 2 (CHRM2) is an acetylcholine receptor that functions as a presynaptic autoreceptor inhibiting acetylcholine release. It is also involved in smooth muscle contractility. In Alzheimer’s disease (AD), selective loss of M2 subtype receptors occurs in cortical and hippocampal regions. Increased M2 receptor heterozygosity has been associated with depression in women. The M2 receptor is expressed in various brain regions including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, as well as in lung and prostate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-90608_CHRM2_P08172-1_Rabbit.svg, PA5-90608_CHRM2_P08172-1_Rabbit_PDP.jpeg)
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