Thermo Fisher Scientific UBC13 Polyclonal Antibody
UBC13 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot에 최적화되어 있습니다. Human, Mouse, Rat 등 다양한 종에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. DNA 손상 복구 및 세포 주기 조절 연구에 유용합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding Ile10 of human Ubc13 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10988857 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical Lys-63-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. It mediates transcriptional activation of target genes and plays roles in cell cycle control, differentiation, and error-free DNA repair.
UBC13 acts with E3 ligases such as HLTF, SHPRH, RNF5, RNF135, and TRAF3IP2 in Lys-63-linked polyubiquitination processes, contributing to DNA repair, immune response, and inflammatory gene expression pathways.
(Information from UniProt)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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