Thermo Fisher Scientific SF3A1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
RQNEINNPKF NFLNPNDPYH AYYRHKVSEF KEGKAQEPSA AIPKVMQQQQ

• Short-term storage: 2–8°C (up to 1 week)
• Long-term storage: -20°C in small aliquots to prevent freeze-thaw cycles

Predicted homology:
Cow: 100%
Dog: 100%
Guinea Pig: 100%
Horse: 100%
Human: 100%
Mouse: 100%
Rabbit: 100%
Rat: 100%
Zebrafish: 93%

Target Information

This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer (subunits 1, 2, and 3) is essential for converting 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing.
Subunit 1 belongs to the SURP protein family, characterized by SURP motifs that mediate RNA binding. The amino-terminal half contains tandem SURP motifs, while the carboxy-terminal half includes a proline-rich region and a ubiquitin-like domain.
Binding studies indicate that SURP motifs are required for interaction with subunit 3, while subunit 2 may bind through sequences C-terminal to the SURP motifs.
Alternative splicing produces multiple transcript variants encoding different isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.