Thermo Fisher Scientific SFRS4 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 0.2–1 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence: RSREESRSRS RSRSKSERSR KRGSKRDSKA GSSKKKKKED TDRSQSRSPS
• Storage guidance:
  • Short term: Store at 2–8°C up to 1 week
  • Long term: Store at -20°C in small aliquots to prevent freeze-thaw cycles
• Predicted homology:
  • Dog: 93%
  • Human: 100%
  • Pig: 86%
  • Rat: 86%

Target Information

Serine/arginine-rich protein 75 (SRp75) is encoded by the SRSF4 gene. SRp75 belongs to the arginine/serine-rich factor family and likely plays a role in alternative mRNA splicing.
The SR factor family members contain one or more RNA recognition motifs (RRM) and an arginine/serine (RS)-rich domain. They are essential for constitutive splicing and regulate alternative splicing in a concentration-dependent manner.
Most SR proteins, including SC35 and SRp40, are localized in the nucleus, while SF2/ASF, SRp20, and 9G8 shuttle between the nucleus and cytoplasm, contributing to mRNA transport. The activity of SR proteins in regulated splicing is antagonized by hnRNP A/B family proteins, which influence splice site selection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.