Thermo Fisher Scientific RRP4 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
AEVQAVFSDG AVSLHTRSLK YGKLGQGVLV QVSPSLVKRQ KTHFHDLPCG

• For short term use, store at 2–8°C up to 1 week.
• For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Predicted homology:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

Target Information

Non-catalytic component of the RNA exosome complex which has 3′→5′ exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events.
In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding pervasive transcripts, and in degradation of mRNAs with processing defects.
In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and RNA surveillance pathways, preventing translation of aberrant mRNAs. It also participates in degradation of histone mRNA.
EXOSC2 as a peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC4 and EXOSC7.
[UniProt]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.