Thermo Fisher Scientific NEK9 Polyclonal Antibody
NEK9 단백질 인산화 조절 연구용 항체로, 인간 시료에 반응하는 Rabbit Polyclonal Antibody입니다. IHC(P)에서 3.6 µg/mL로 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 단기 4℃, 장기 -20℃ 보관 권장.
- 판매단위
- pk
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Applications
Tested Application and Dilution
- Immunohistochemistry (Paraffin) (IHC (P)): 3.6 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 19 amino acid peptide from Pro/Ser/Thr rich domain of human NEK9 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551328 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Gorilla, Gibbon (100%); Monkey, Marmoset (89%).
Target Information
NEK9 is a NEK-type protein kinase that regulates chromosome alignment and segregation during mitosis.
It contains:
- An N-terminal NIMA-like catalytic domain
- A central domain homologous to the guanine nucleotide exchange factor for GTPase Ran (RCC1)
- A C-terminal coiled-coil domain
NEK9 is phosphorylated by active p34(Cdc2), capable of autophosphorylation and oligomerization.
Activated NEK9 binds Nek6 and RCC1, associates with the human homolog of Drosophila Bicd2, and phosphorylates this coiled-coil protein in vitro.
Expression is observed in normal human brain, and ESTs have been identified from various tissue libraries including normal bone, lymph, thymus, and cancerous cervix, eye, lymph, and placenta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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