Thermo Fisher Scientific CD31/PECAM-1 (Endothelial Cell Marker) Monoclonal Antibody (SPM532)
CD31/PECAM-1 단일클론 항체로 혈관내피세포 마커 검출에 적합합니다. Western blot, IHC, ICC, Flow cytometry 등 다양한 응용 가능. 인간 시료 반응성, Mouse IgG1 항체. 연구용으로만 사용.
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Thermo Fisher Scientific CD31/PECAM-1 (Endothelial Cell Marker) Monoclonal Antibody (SPM532)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM532 |
| Immunogen | Human recombinant CD31 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling via immunoreceptor tyrosine-based inhibitory motifs (ITIM). Upon phosphorylation, these motifs provide docking sites for protein-tyrosine phosphatases. CD31 is widely expressed within the vascular compartment, mainly at junctions between adjacent cells. Its N-terminal Ig-like domain mediates homophilic binding, important for cell-cell interactions. CD31 plays key roles in integrin-mediated adhesion, transendothelial migration, angiogenesis, apoptosis, immune regulation, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis, and thrombosis. It is one of the key regulatory molecules in the vascular system.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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