Thermo Fisher Scientific TNFRSF21 Monoclonal Antibody (2C11)

Applications

Tested Dilution

Publications

ELISA (ELISA)

10 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

2C11

Immunogen

TNFRSF21 (AAH17730.1, 47 a.a. approximately 349 a.a) partial recombinant protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:DR6,uniProtId:O75509-1,ncbiNodeId:9606,antigenRange:47-349,antigenLength:655,antigenImageFileName:H00027242-M38_DR6_O75509-1_House_mouse.svg,antigenImageFileNamePDP:H00027242-M38_DR6_O75509-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: ASNLIGTYRH VDRATGQVLT CDKCPAGTYV SEHCTNTSLR VCSSCPVGTF TRHENGIEKC HDCSQPCPWP MIEKLPCAAL TDRECTCPPG MFQSNATCAP HTVCPVGWGV RKKGTETEDV RCKQCARGTF SDVPSSVMKC KAYTDCLSQN LVVIKPGTKE TDNVCGTLPS FSSSTSPSPG TAIFPRPEHM ETHEVPSSTY VPKGMNSTES NSSASVRPKV LSSIQEGTVP DNTSSARGKE DVNKTLPNLQ VVNHQQGPHH RHILKLLPSM EATGGEKSST PIKGPKRGHP RQNLHKHFDI NEH

Target Information

DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-kappa-B and JNK.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.