ELK Biotechnology Estrogen Receptor α rabbit pAb

ELK Biotechnology Estrogen Receptor α rabbit pAb

제품 개요

이 항체는 에스트로겐 수용체 α(Estrogen Receptor α)에 특이적인 rabbit polyclonal antibody로, 호르몬 결합, DNA 결합 및 전사 활성화에 관여하는 핵 수용체 단백질을 검출하는 데 사용됩니다. 에스트로겐 수용체는 생식 기능뿐 아니라 뼈, 유방, 자궁 내막 등 다양한 조직에서 중요한 역할을 하며, 유방암 및 골다공증 등 병리적 과정에도 관련되어 있습니다.

제품 스펙

세포 내 위치

• Isoform 1: Nucleus, Cytoplasm, Cell membrane; Peripheral membrane protein (Cytoplasmic side). A minor fraction is associated with the inner membrane.
• Isoform 3: Nucleus, Cytoplasm, Cell membrane; Peripheral membrane protein; Cytoplasmic side. Single-pass type I membrane protein associated with the inner membrane via palmitoylation (Probable).
  Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus, where palmitoylation occurs. Associated with the plasma membrane when palmitoylated.

Background

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and transcription activation. The protein localizes mainly to the nucleus and can form homodimers or heterodimers with estrogen receptor 2. Estrogen receptors are essential for sexual development and reproductive function and are also implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and splicing generate multiple transcript variants, though full-length sequences for many remain undetermined. (RefSeq, Mar 2014)