ELK Biotechnology RSK3 (Phospho Thr353) rabbit pAb

제품명

RSK3 (Phospho Thr353) rabbit pAb

제품 설명

RSK3 (Phospho Thr353) rabbit pAb는 인산화된 Thr353 부위의 RSK3 단백질을 특이적으로 인식하는 항체로, 세포 내 신호전달 경로 및 CREB 전사인자 활성화 연구에 유용하게 사용됩니다.
인간과 마우스 시료에서 반응하며, Western blot(WB) 및 ELISA 분석에 적합합니다.

제품 정보

Background

• Catalytic activity: ATP + a protein = ADP + a phosphoprotein
• Cofactor: Magnesium
• Enzyme regulation: Activated by multiple phosphorylations on threonine and serine residues
• Function: Serine/threonine kinase that may play a role in mediating the growth-factor and stress-induced activation of the transcription factor CREB
• PTM: Autophosphorylated on Ser-377 as part of the activation process
• Similarity: Belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, S6 kinase subfamily
• Domain structure: Contains 1 AGC-kinase C-terminal domain and 2 protein kinase domains
• Subunit: Forms a complex with either ERK1 or ERK2 in quiescent cells; transiently dissociates following mitogenic stimulation
• Tissue specificity: Expressed in many tissues, with highest expression in lung and skeletal muscle