Thermo Fisher Scientific DLL4 Recombinant Rabbit Monoclonal Antibody (004)
Mouse DLL4 단백질을 인식하는 재조합 토끼 단클론 항체로 높은 특이성과 민감도를 제공. ELISA 등 다양한 연구용 응용에 적합하며, 보존제가 없는 액상 형태로 제공. 로트 간 일관성과 동물 유래 성분이 없는 포뮬레이션으로 안정적 실험 수행 가능.
- 카탈로그번호
- MA531109
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Thermo Fisher Scientific DLL4 Recombinant Rabbit Monoclonal Antibody (Clone 004)
Applications
- ELISA
Tested Dilution: 1:250–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 004 |
| Immunogen | Recombinant Mouse DLL4/Delta-like 4 Protein (Met1–Pro525) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C (short term), -20°C (long term). Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2786761 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Antibody DNA sequences from immunoreactive rabbits are cloned and screened to select optimal clones for production.
Advantages:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broad immunoreactivity due to large rabbit immune repertoire
This antibody has specificity for Mouse DLL4/Delta-like 4.
Target Information
Delta-like ligand 4 (DLL4), also known as Delta-4, is a transmembrane ligand for the Notch1 receptor. It is expressed in vasculature and plays a key role in vascular development. DLL4 expression is induced by VEGF and acts as a negative feedback regulator of angiogenesis. It is strongly expressed in tumor vessels of clear-cell renal and bladder cancers. Inhibition of DLL4 increases vascular proliferation but leads to defective maturation, resulting in reduced tumor growth without apparent toxicity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.
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