Thermo Fisher Scientific TEM7 Monoclonal Antibody (13)

Applications

• ELISA (ELISA)
  Tested Dilution: 1:1,000–1:2,000

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).
This antibody has specificity for Human TEM7/PLXDC1.

Target Information

Using SAGE (Serial Analysis of Gene Expression) technology, St. Croix et al. identified 46 genes whose expression is specifically elevated in tumor-associated endothelium. Nine of these genes were prominently expressed only in tumor endothelial cells (ECs) and named Tumor Endothelial Markers (TEMs, TEM1–9).
TEM7 transcripts are specifically expressed in the endothelium of colorectal cancer, as well as in primary cancers of lung, pancreas, breast, and brain. TEM7 expression is consistent across both primary and metastatic sites. Other family members (TEM1, 3, 4, 5, 8, and 9) show similar expression patterns in lung and brain tumors and liver metastasis.
These genes may serve as valuable resources for basic and clinical studies of human angiogenesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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