Thermo Fisher Scientific uPAR Recombinant Rabbit Monoclonal Antibody (014)

Applications and Tested Dilution

Product Specifications

Product Specific Information

This product is preservative-free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%–0.1%).

Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The antibody DNA sequences from immunoreactive rabbits are cloned and expressed in HEK293 cells. Individual clones are screened to select the best candidates for production.

Advantages of recombinant rabbit monoclonal antibodies:

• High specificity and sensitivity
• Lot-to-lot consistency
• Animal origin-free formulation
• Broad immunoreactivity due to large rabbit immune repertoire

This antibody specifically recognizes Mouse PLAUR/CD87.

Target Information

The urokinase-type plasminogen activator receptor (uPAR) regulates cell-surface plasminogen activation and plays a key role in both normal and pathological processes. The human PLAUR cDNA encodes 335 amino acids, including a signal peptide and a hydrophobic C-terminal portion, producing a highly glycosylated ~50 kDa protein anchored to the plasma membrane by a GPI linkage.

PLAUR (uPAR) associates with the carbohydrate-binding domain of SELL on neutrophil membranes, mediating calcium mobilization in a SELL-dependent manner. Elevated UPAR mRNA levels correlate with the invasive potential and advanced stages of endometrial carcinomas, as well as recurrence and mortality rates, making UPAR a potential prognostic marker for advanced endometrial cancer.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.