Thermo Fisher Scientific DKC1 Polyclonal Antibody
Rabbit polyclonal antibody against human DKC1 protein. Validated for WB, IHC(P), and ICC/IF applications. High purity (>95%) via antigen affinity chromatography. Suitable for research use in rRNA processing and telomerase complex studies.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full-length Human DKC1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719764 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. Purity is greater than 95% (by SDS-PAGE).
Target Information
The DKC1 gene encodes a member of the H/ACA snoRNPs family, involved in rRNA processing and modification. H/ACA snoRNPs include NOLA1, NOLA2, and NOLA3 proteins, which localize to nucleoli and coiled bodies in the nucleus. Depletion of any of these proteins impairs 18S rRNA production and rRNA pseudouridylation. These proteins are also components of the telomerase complex. The DKC1 protein is homologous to yeast Cbf5p and Drosophila Nop60B. Mutations in DKC1 cause X-linked dyskeratosis congenita and Hoyeraal-Hreidarsson syndrome. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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