Thermo Fisher Scientific POLI Polyclonal Antibody
DNA Polymerase Iota의 C-말단 펩타이드에 특이적인 rabbit polyclonal antibody로, WB와 ICC/IF에 적합합니다. Human 및 Mouse 반응성을 가지며, whole serum 형태로 제공됩니다. 연구용으로 DNA 손상 복구 및 translesion synthesis 연구에 활용됩니다.
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- PA316539
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:250
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15-mer peptide in the C-terminal region of human DNA Polymerase Iota, conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2167016 |
Product Specific Information
Suggested positive control: HeLa whole cell extract (100 µg) or GM0193 (lymphoblastoid cell line).
Target Information
Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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