Thermo Fisher Scientific MLLT10 Polyclonal Antibody
MLLT10 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot에 최적화되어 있으며, 고순도의 Affinity chromatography 정제 제품. 인체 시료 반응성, 1 mg/mL 농도, 안정한 PBS/BSA/glycerol 버퍼에 보관.
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Applications
- Western Blot (WB): 1:500 dilution
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide conjugated to KLH derived from within residues 200–300 of Human MLLT10 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Translocations affecting chromosome 11q23 involve many partner chromosome regions and occur in various leukemias. The 11q23 gene involved in the translocations is MLL. MLLT10 is the partner gene to MLL1 involved in t(10;11)(p12;q23) translocations.
In leukemia, the MLL1 gene (a SET domain-containing histone methyltransferase) fuses with the MLLT10 gene, producing a 1,027-amino acid protein containing an N-terminal zinc finger and a C-terminal leucine zipper domain.
MLLT10 can also be rearranged with the CALM gene in the t(10;11)(p12;q14) translocation. Chimeric fusion proteins MLL/AF10 and CALM/AF10 retain the leucine zipper motif, which interacts with GAS41 and INI1, components of the SWI/SNF chromatin remodeling complex.
These interactions suggest that the chimeric proteins may interfere with normal gene regulation through chromatin remodeling mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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