Thermo Fisher Scientific SERTAD1 Polyclonal Antibody

Applications and Tested Dilution

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

This antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.

Target Information

SEI-1, also known as SERTAD1 (SERTA domain containing 1) or TRIP-Br1 (Transcriptional regulator interacting with the PHD-bromodomain 1), is a transcriptional regulator that integrates signals from transcription factors.
At E2F-responsive promoters, SEI-1 interacts with the PHD- and bromodomains of proteins such as TIF1 and DP-1, transmitting their signals to the promoter and stimulating transcriptional activity.
SEI-1 forms a multiprotein complex with E2F-1 and DP-1 and is expressed at varying levels throughout the cell cycle, allowing regulation of cell cycle progression during the G1 and S phases.
Additionally, SEI-1 can render the cyclin D-Cdk4 complex resistant to the inhibitory effects of p16. Overexpression of SEI-1 has been implicated in the development of squamous cell carcinomas of the head and neck.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.