Thermo Fisher Scientific Aggrecan Recombinant Rabbit Monoclonal Antibody (6L4T2)
Aggrecan 단백질을 표적하는 토끼 유래 재조합 단클론 항체로, WB, IHC, ELISA 등에 사용 가능. HEK293 세포에서 발현되었으며, 고순도 Affinity Chromatography로 정제됨. 연골 조직 연구 및 Aggrecan 관련 질환 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:4,000 | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | – |
| ELISA | 1 µg/mL | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 6L4T2 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 761–861 of human Aggrecan (P16112) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2911787 |
Product Specific Information
The target is usually found in the following locations: secreted, extracellular matrix, extracellular space.
Immunogen sequence:
WPPTGAATEE STEGPSATEV PSASEEPSPS EVPFPSEEPS PSEEPFPSVR PFPSVELFPS EEPFPSKEPS PSEEPSASEE PYTPSPPVPS WTELPSSGEE S
Target Information
Aggrecan, also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is encoded by the ACAN gene. It is a major structural component of the extracellular matrix in cartilage, providing resistance to compression. The human protein consists of 2316 amino acids (~250 kDa) and exists in multiple isoforms due to alternative splicing.
Aggrecan exhibits a bottlebrush structure with chondroitin sulfate and keratan sulfate chains attached to a protein core. Its synthesis and degradation are key processes in cartilage deterioration during joint injury, disease, and aging. It contains three interglobular domains (G1, G2, G3) involved in aggregation, hyaluronan binding, cell adhesion, and chondrocyte apoptosis.
Aggrecan fragments are released into synovial fluid during all stages of human osteoarthritis due to cleavage by aggrecanase and MMP activity. Antibodies BC-3 and BC-4 detect neo epitopes of Aggrecanase (ARGSVXXX) and MMP (XXXVDIPEN), respectively.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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